Polycystic Ovarian Syndrome (PCOS) leads to a lack of ovulation in addition to a range of other symptoms. Women with PCOS have an increased chance of multiple births at each pregnancy, and the chance increases with the use of fertility medication.
Women with PCOS who are able to get pregnant have a 7 to 10 percent greater chance of having multiple births than women who do not have the condition, notes Washington University's Infertility and Reproductive Medicine Center.
Women with PCOS are often given the fertility medication clomiphene citrate to help treat their lack of ovulation when trying to get pregnant. Women who take the medication have a 20 to 25 percent higher-than-average chance of having multiple births, according to Washington University.
Women with PCOS who are expecting a multiple birth are at a greater chance for certain pregnancy complications, notes the National Women's Health Information Center website. Complications include miscarriage, gestational diabetes, preeclampsia, early delivery, newborn death or a stay in the neonatal intensive care unit.